The present study was aimed to evaluate antidiabetic activity of the Ruellia tuberosa (Acanthaceae) in nicotinamide-strerptozotocin (NAD-STZ) induced type-II diabetes in wistar albino rats. The methanolic extract stem and root were studied at three dose level (200mg/ kg, 300mg/ kg 400 mg/ kg), administered for 15 days. The Metformin (15mg/kg) was used as positive control. Serum glucose levels were estimated by on 0, 10th and 15th day of the treatment. The serum cholesterol and HDL levels were estimated in all groups and compared against diabetic control group. The methanol extract of stem and root were showed a significant reduction of serum glucose level and total cholesterol level in diabetic rats on 15th day of treatment when compared against diabetic control groups (p < 0.05). HDL cholesterol levels were also improved in the treated diabetic rats. It is concluded that the R. tuberosa stem and root both possess antidiabetic activity in nicotinamide- strerptozotocin induced type –II diabetic rats and further studies are suggested to isolate the active principle responsible for the activity.
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